bone remodeling
| PAG Title | bone remodeling |
| PAG ID | WAG000641 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Bone density and structure is maintained through a balance of bone resorption by osteoclasts and bone deposition by osteoblasts. The combition of simultaneous resorption and deposition creates continual remodeling of bone while excess osteoclast activity leads to an imbalance and a loss of bone density, causing osteoporosis. RANK (receptor activator of NF-kB ligand) is a receptor in the TNF receptor gene family that is involved in osteoclast differentiation. RANK-ligand, also called osteoprotegerin-ligand, binds to RANK, induces receptor dimerization, and activates downstream sigling. Osteoprotegerin is a decoy receptor for RANK-ligand that suppresses osteoclast activity and bone remodeling, helping to maintain balanced bone remodeling. RANK-ligand and osteoprotegerin are produced by osteoblasts and some factors regulate osteoclast activity indirectly through their action on the expression of these factors by osteoblasts. |
| Species | Homo sapiens |
| nCoCo Score | 954 |
| Base PAG ID | WAG000641 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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